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Carbon‐13 nuclear magnetic resonance spectra of anti‐inflammatory drugs: Phenylbutazone, oxyphenbutazone and indomethacin
Author(s) -
Singh S. P.,
Parmar S. S.,
Stenberg V. I.,
Farnum S. A.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150103
Subject(s) - oxyphenbutazone , chemistry , phenylbutazone , protonation , chemical shift , nuclear overhauser effect , acetic acid , spectral line , carbon 13 nmr , nmr spectra database , carbon 13 , benzene , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , organic chemistry , stereochemistry , medicinal chemistry , ion , pharmacology , medicine , physics , quantum mechanics , astronomy
The 13 C nmr chemical shifts of phenylbutazone, oxyphenbutazone, indomethacin and indole‐3‐acetic acid are reported. The assignments of various carbon resonances are made on the basis of the substitution effects on benzene shifts, multiplicities generated in SFORD spectra, nuclear overhauser enhancement for protonated carbons, and the comparison with analogous compounds.