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Reactivity of 2‐amino‐1,3,4‐thiadiazoles. Nucleophilic behaviour of some 2‐amino‐1,3,4‐thiadiazoles: Model compounds
Author(s) -
Werber Giuseppe,
Buccheri Francesco,
Gentile Manlio
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140727
Subject(s) - thiadiazoles , chemistry , nucleophile , acylation , reactivity (psychology) , alkylation , nitrosation , nucleophilic addition , medicinal chemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
Abstract The ambident nucleophilic behaviour of some 2‐amino‐5‐ H ‐1,3,4‐thiadiazoles in alkylation, acylation and nitrosation reaction has been verified. The structures assigned to the 2‐amino‐1,3,4‐thiadiazoles ( 1a‐i ) and to the Δ 2 ‐1,3,4‐thiadiazolines ( 2a‐e ) agree with the spectral data.