Premium
A convenient synthesis of 2‐chromonecarboxylic acids
Author(s) -
Pifferi Giorgio,
Gaviraghi Giovanni,
Pinza Mario,
Ventura Paolo
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140725
Subject(s) - chemistry , knoevenagel condensation , methylene , glyoxylate cycle , condensation , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , physics , thermodynamics , enzyme
Knoevenagel condensation of the β‐ketosulfinyl intermediate II with butyl glyoxylate afforded the butyl 2‐hydroxy‐4‐(2‐hydroxyphenyl)‐3‐methylsulfinyl‐4‐oxobutyrates (III). Compounds III are versatile intermediates for the synthesis of either 2‐chromonecarboxylates (V) or 2‐carboxy‐methylene‐3‐coumaranone esters (VII).