Synthesis of some 7‐α‐carboxyethyl‐1,3‐dihydro‐(2 H )‐1,4‐benzodiazepin‐2‐ones | Zendy

Žinić M. | Zendy; Kolbah D. | Zendy; Blažević N. | Zendy; Kajfež F. | Zendy; Šunjić V. | Zendy

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Synthesis of some 7‐α‐carboxyethyl‐1,3‐dihydro‐(2 H )‐1,4‐benzodiazepin‐2‐ones

Author(s) -

Žinić M.,

Kolbah D.,

Blažević N.,

Kajfež F.,

Šunjić V.

Publication year - 1977

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570140719

Subject(s) - chemistry , derivative (finance) , nitro , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl , financial economics , economics

1,4‐Benzodiazepin‐2‐ones possessing an α‐carboxyethyl group in 7‐position (21‐25) were prepared from a key compound, 2‐amino‐5‐α‐carboxyethylbenzophenone (8) or from its O ‐benzyl derivative 14 , using methods developed previously. An optimized route to 8 starting from 2‐nitro‐5‐chlorobenzophenone ( 1 ), as well as some unsuccessful attempts are described. Compound 8 was deaminated into racemic α‐(3‐benzoyl)‐phenylpropionic acid ( 9 ), a well‐known antiinflammatory agent.

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