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Synthesis of some 7‐α‐carboxyethyl‐1,3‐dihydro‐(2 H )‐1,4‐benzodiazepin‐2‐ones
Author(s) -
Žinić M.,
Kolbah D.,
Blažević N.,
Kajfež F.,
Šunjić V.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140719
Subject(s) - chemistry , derivative (finance) , nitro , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl , financial economics , economics
1,4‐Benzodiazepin‐2‐ones possessing an α‐carboxyethyl group in 7‐position (21‐25) were prepared from a key compound, 2‐amino‐5‐α‐carboxyethylbenzophenone (8) or from its O ‐benzyl derivative 14 , using methods developed previously. An optimized route to 8 starting from 2‐nitro‐5‐chlorobenzophenone ( 1 ), as well as some unsuccessful attempts are described. Compound 8 was deaminated into racemic α‐(3‐benzoyl)‐phenylpropionic acid ( 9 ), a well‐known antiinflammatory agent.