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Synthesis and antimalarial effects of [1]benzothieno[3,2‐ f ]quinazoline‐1,3‐diamine
Author(s) -
Johnson Judith,
Elslager Edward F.,
Werbel Leslie M.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140716
Subject(s) - chemistry , quinazoline , diamine , hydrochloride , halogenation , derivative (finance) , medicinal chemistry , stereochemistry , organic chemistry , financial economics , economics
Bromination of 2‐dibenzothiophenamine has been shown to afford 1‐bromo‐2‐dibenzothio‐phenamine rather than the previously reported 3‐isomer. This material was converted to the 1‐cyano derivative and cyclized with chloroformamidine hydrochloride to [l]benzothieno‐[3,2‐ f ]quinazoline‐1,3‐diamine. Both this and the corresponding 7,7‐dioxide were devoid of antimalarial activity.