Synthesis and antimalarial effects of [1]benzothieno[3,2‐ f ]quinazoline‐1,3‐diamine | Zendy

Johnson Judith | Zendy; Elslager Edward F. | Zendy; Werbel Leslie M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis and antimalarial effects of [1]benzothieno[3,2‐ f ]quinazoline‐1,3‐diamine

Author(s) -

Johnson Judith,

Elslager Edward F.,

Werbel Leslie M.

Publication year - 1977

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570140716

Subject(s) - chemistry , quinazoline , diamine , hydrochloride , halogenation , derivative (finance) , medicinal chemistry , stereochemistry , organic chemistry , financial economics , economics

Bromination of 2‐dibenzothiophenamine has been shown to afford 1‐bromo‐2‐dibenzothio‐phenamine rather than the previously reported 3‐isomer. This material was converted to the 1‐cyano derivative and cyclized with chloroformamidine hydrochloride to [l]benzothieno‐[3,2‐ f ]quinazoline‐1,3‐diamine. Both this and the corresponding 7,7‐dioxide were devoid of antimalarial activity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research