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A new facile synthesis of 5‐arninopyridazine‐4‐carboxylic acid
Author(s) -
Chimichi S.,
Nesi R.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140634
Subject(s) - chemistry , yield (engineering) , carboxylic acid , pyridine , ring (chemistry) , benzoyl chloride , chloride , acid anhydride , organic chemistry , dicarboxylic acid , medicinal chemistry , materials science , epoxy , metallurgy
Hofmann rearrangement of 5‐carbamylpyridazine‐4‐carboxylic acid ( 6 ), obtained from pyrida‐zine‐4,5‐dicarboxylic acid ( 3 ) through the corresponding anhydride ( 5 ), afforded 5‐aminopyrida‐zine‐4‐carboxylic acid ( 1 ) in good yield. Compound 1 cyclised with benzoyl chloride in pyridine to give 2‐phenylpyridazino[ 4 ,5‐ d ]‐1,3‐oxazin‐4‐one ( 7 ), a new heterocyclic ring system. J. Heterocyclic Chem. , 14, 1099 (1977)