Chemistry of the phenoxathiins i. Synthesis of 1‐azaphenoxathiin analogs as potential new CNS depressant agents | Zendy

Martin G. E. | Zendy; Turley J. C. | Zendy; Williams L. | Zendy; Steenberg M. L. | Zendy; Buckley J. P. | Zendy

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Chemistry of the phenoxathiins i. Synthesis of 1‐azaphenoxathiin analogs as potential new CNS depressant agents

Author(s) -

Martin G. E.,

Turley J. C.,

Williams L.,

Steenberg M. L.,

Buckley J. P.

Publication year - 1977

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570140624

Subject(s) - chemistry , depressant , yield (engineering) , substituent , salt (chemistry) , condensation , stereochemistry , organic chemistry , pharmacology , medicine , materials science , physics , metallurgy , thermodynamics

The condensation of the disodium salt of 2‐mercapto‐3‐pyridinol with various ortho ‐nitrohalo‐benzenes to yield a group of previously unreported 1‐azaphenoxathiins is described. The synthetic pathway and the substituent location on the products is unequivocably demonstrated by Fourier Transform 1 3 C‐nmr. Preliminary pharmacologic evaluation of the title compounds as potential CNS depressant agents is also reported.

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