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Chemistry of the phenoxathiins i. Synthesis of 1‐azaphenoxathiin analogs as potential new CNS depressant agents
Author(s) -
Martin G. E.,
Turley J. C.,
Williams L.,
Steenberg M. L.,
Buckley J. P.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140624
Subject(s) - chemistry , depressant , yield (engineering) , substituent , salt (chemistry) , condensation , stereochemistry , organic chemistry , pharmacology , medicine , materials science , physics , metallurgy , thermodynamics
The condensation of the disodium salt of 2‐mercapto‐3‐pyridinol with various ortho ‐nitrohalo‐benzenes to yield a group of previously unreported 1‐azaphenoxathiins is described. The synthetic pathway and the substituent location on the products is unequivocably demonstrated by Fourier Transform 1 3 C‐nmr. Preliminary pharmacologic evaluation of the title compounds as potential CNS depressant agents is also reported.