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Synthesis of alkyl indole derivatives
Author(s) -
Shaikh Yunus A.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140620
Subject(s) - chemistry , indole test , condensation , alkyl , medicinal chemistry , organic chemistry , stereochemistry , combinatorial chemistry , thermodynamics , physics
Condensation of arylamines with α‐halogenoketone afforded the intermediate anilino‐ketones which on direct cyclization furnished the corresponding alkylindoles. Synthesis of 2,3,5‐trimethyl‐4,7‐dimethoxyindole (5a) and 2,3,6‐trimethyl‐7‐methoxyindole (5b) is described. Earlier (1) synthesis of 2,3‐dimethyl‐4,7‐dimethoxyindole and 1,2,3‐trimethyl‐4,7‐dimethoxy‐indole is reported.