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1,3‐Oxazolidin‐4‐ones. Synthesis and configuration of cis and trans isomers
Author(s) -
Pilgram Kurt,
Pollard Glenn E.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140616
Subject(s) - chemistry , boron trifluoride , column chromatography , cis–trans isomerism , boron , organic chemistry , catalysis
Mixtures of cis and trans 1,3‐oxazolidin‐4‐ones were obtained by cyclodehydration, in the presence of p ‐toluenesulfonic acid or boron trifluoride etherate, of lactamide and N ‐methyl‐lactamide with aromatic and aliphatic aldehydes. The products were separated by column (silica) chromatography and their configurations were determined.