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Studies on the chemistry of 2,3,5,6‐tetrahydro‐6‐phenylimidazo[2,l‐ b ]‐thiazole. III. . Reaction with isocyanates and isothiocyanates
Author(s) -
Bigg D. C. H.,
Faull A. W.,
Purvis S. R.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140608
Subject(s) - chemistry , adduct , thiazole , aryl , medicinal chemistry , alkyl , organic chemistry
2,3,5,6‐Tetrahydro‐ b ‐phenylimidazo[2,l ‐b‐ ]thiazole reacts with aryl isothiocyanates to give dipolar 1:1 adducts. The adducts are relatively unstable and, in solution, exist in equilibrium with starting materials. The reaction with aryl and alkyl isocyanates, however, leads to cyclic 2:1 adducts, while sulphonyl and acyl isocyanates give stable dipolar 1:1 adducts. J. Chem. Soc. , 14, 989 (1977)