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Synthesis of a pyrano[2,3‐ b ] pyridine with vinylogous hydroxamic acid structures
Author(s) -
Löwe Werner
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140542
Subject(s) - chemistry , pyridine , hydroxylamine , ring (chemistry) , acetic acid , hydroxamic acid , dimethylformamide , derivative (finance) , lactone , stereochemistry , medicinal chemistry , organic chemistry , solvent , financial economics , economics
A new, two step synthesis of a pyrano[2,3‐ b ]pyridine derivative 5 is described. Dehydro‐acetic acid and N,N ‐dimethylformamide dimethylacetal was condensed to form 2 . Compound 2 was converted into 5 by reaction with hydroxylamine which opens the lactone ring.