Premium
Synthesis and 270 MHz Nmr structural studies of the isomers of 2,3,5‐trimethyl‐ and 2,3,6‐trimethylmorpholine
Author(s) -
Hernestam Sven,
Nilsson Bertil,
Stenvall Gillis
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140535
Subject(s) - chemistry , methylene , coupling constant , chemical shift , proton nmr , structural isomer , organic chemistry , physics , particle physics
The four isomers of 2,3,5‐trimethylmorpholine and those of 2,3,6‐trimethylmorpholine have been synthesized from appropriately substituted ethanolamines and separated by means of preparative gas‐liquid chromatography. The configuration of each isomer was determined from 270 MHz FT‐nmr studies of the magnitudes of the methine‐methine and methine‐methylene proton coupling constants. The evaluated chemical shifts of axial methyl groups are discussed.