Premium
Thieno [2,3 ‐ b ] pyridines and thieno [ 3,2 ‐ b ] pyridines by the method of gould‐jacobs
Author(s) -
Khan Misbahul Ain,
Guarçoni Antonio Elydio
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140519
Subject(s) - chemistry , pyridine , methylene , condensation , medicinal chemistry , ether , diphenyl ether , organic chemistry , stereochemistry , physics , thermodynamics
Bis(2‐, and 3‐thienylammonium) hexachlorostannates were condensed with ethoxymethylene derivatives of active methylene compounds in pyridine. The resulting condensation products IVa‐IVc and Va‐Vc on heating under reflux in Dowtherm or diphenyl ether provided various 4‐hydroxythieno[2,3‐ b ] pyridines (Ia‐Ic) and 7‐hydroxythieno[3,2‐ b ]pyridines (IIa‐IIc). The compound Ic on further transformations gave yet other derivatives If‐Ik.