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Studies on the chemistry of 2,3,5,6‐Tetrahydro‐6‐phenylimidazo[2,1‐ b ]‐thiazole. I. The reaction of N ‐Alkyl derivatives with nucleophiles
Author(s) -
Bigg D. C. H.,
Faull A. W.,
Purvis S. R.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140413
Subject(s) - chemistry , nucleophile , thiazole , alkyl , ring (chemistry) , medicinal chemistry , organic chemistry , stereochemistry , catalysis
7‐Alkyl‐2,3,5,6‐tetrahydro‐6‐pheriylimidazo[2,1‐ b ]thiazoliurn salts behave as arnbident electro‐philes, which give ring‐opened products on reaction with a variety of nucleophiles. The results are rationalised in terms of thermodynamic or kinetic control.