Pyrazolopyrimidine nucleosides. Part VIII  The synthesis of certain 4‐substituted pyrazolo[3,4‐ d ]pyrimidine nucleosides | Zendy

Montero Jean Louis G. | Zendy; Bhat Ganapati A. | Zendy; Panzica Raymond P. | Zendy; Townsend Leroy B. | Zendy

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Pyrazolopyrimidine nucleosides. Part VIII The synthesis of certain 4‐substituted pyrazolo[3,4‐ d ]pyrimidine nucleosides

Author(s) -

Montero Jean Louis G.,

Bhat Ganapati A.,

Panzica Raymond P.,

Townsend Leroy B.

Publication year - 1977

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570140326

Subject(s) - chemistry , pyrimidine , nucleoside , aryl , stereochemistry , riboside , alkyl , organic chemistry , biochemistry

1‐(β‐D‐Ribofuranosyl)pyrazolo[3,4‐ b ]pyrimidine‐4‐thione ( 6 ), obtained by a three‐step synthesis from allopurinol riboside (3), was treated with certain alkyl and aryl halides to provide the corresponding 4‐alkylthio derivatives. The nucleoside 4‐methylthio‐1‐(β‐D‐ribofuranosyl)pyra‐zolo[3,4‐ d ]pyritnidine ( 7 ) has served as the precursor for the preparation of the 4‐methylamino ( 11 ), 4‐dimethylamino ( 12 ), 4‐hydrazino ( 13 ), and the 4‐hydroxylamino ( 14 ) analogs.

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