Studies on the synthesis of chemotherapeutics.  I . Synthesis of 1‐(2‐tetrahydrofuryl)‐5‐fluorouracil [ftorafur] (studies on the syntheses of heterocyclic compounds. Part 703) | Zendy

Kametani Tetsuji | Zendy; Kigasawa Kazuo | Zendy; Hiiragi Mineharu | Zendy; Wakisaka Kikuo | Zendy; Kusama Osamu | Zendy; Kawasaki Kumeo | Zendy; Sugi Hideo | Zendy

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Studies on the synthesis of chemotherapeutics. I . Synthesis of 1‐(2‐tetrahydrofuryl)‐5‐fluorouracil [ftorafur] (studies on the syntheses of heterocyclic compounds. Part 703)

Author(s) -

Kametani Tetsuji,

Kigasawa Kazuo,

Hiiragi Mineharu,

Wakisaka Kikuo,

Kusama Osamu,

Kawasaki Kumeo,

Sugi Hideo

Publication year - 1977

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570140324

Subject(s) - chemistry , fluorouracil , yield (engineering) , combinatorial chemistry , stereochemistry , chemotherapy , medicine , materials science , metallurgy

Synthesis of 1‐(2‐tetrahydrol'uryl)‐5‐fluorouracil [Ftorafur] ( 1 ) which is well known as an antitumor agent from 5‐fluorouracil ( 2 ) with 2‐alkoxytetrahydrofurans (4) is described. Among these reactions, the best yield was obtained by using 2‐ t ‐butoxytetrahydrofuran (4h).

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