Premium
Intramolecular nucleophilic cyclization of a carboxylic acid hydrazide under mild acid conditions
Author(s) -
Martin Gary E.,
Munson James W.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140241
Subject(s) - chemistry , phthalimide , hydrazide , nucleophile , carboxylic acid , intramolecular force , ring (chemistry) , aqueous solution , medicinal chemistry , organic chemistry , catalysis
Abstract Phthaloyl‐2′‐nitrophenylhydrazide undergoes ring closure involving nucleophilic attack of the hydrazide on the carboxylic acid in dilute aqueous acid solution to form the corresponding N ‐substituted phthalimide. Structure of the resulting phthalimide was unequivocally confirmed by 13 C‐nmr.