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Novel two step synthesis of pyrazoles and isoxazoles from aryl methyl ketones
Author(s) -
Lin Yangi,
Lang S. A.
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140240
Subject(s) - chemistry , hydrazine (antidepressant) , hydroxylamine , hydrate , aryl , dimethylformamide , acetal , organic chemistry , pyrazole , medicinal chemistry , solvent , alkyl , chromatography
Abstract Various acetyl aromatics when reacted with dimethylformamide dimethyl acetal gave 1‐aryl‐3‐dimethylamino‐2‐propen‐1‐ones. These intermediates are masked β‐ketoaldehydes and react with hydrazine hydrate or hydroxylamine at room temperature to give in good yields pyrazoles or isoxazoles.