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Studies on the oeearboxylation reactions. Note II . Kinetic study of the decarboxylation reaction of 5‐amino‐1,3,4‐thiadiazole‐2‐carboxylic acid (I) to 2‐amino‐1,3,4‐thiadiazole (III)
Author(s) -
Spinelli Domenico,
Noto Renato,
Consiglio Giovanni,
Buccheri Francesco
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140229
Subject(s) - chemistry , decarboxylation , amino acid , reaction rate constant , reaction mechanism , carboxylic acid , medicinal chemistry , kinetic energy , oxadiazole , reaction rate , stereochemistry , organic chemistry , kinetics , catalysis , biochemistry , physics , quantum mechanics
The rate constants of the deearboxylation reaction in water of 5‐amino‐1,3,4‐lhiadiazole‐2‐carboxylic acid (I) to 2‐amino‐1,3,4‐thiadiazole (III) over the p H range O.25‐3.91 have been measured and the activation parameters determined. The results obtained have been compared with previous results on the deearboxylalion of 5‐amino‐1,3,4‐oxadiazole‐2‐earboxylic acid (II) to gain information on the mechanism of the reaction studied.