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A new, one‐step transformation of furoic acid derivatives to 2‐Amino‐3‐hydroxypyridines
Author(s) -
Greater Hans,
Belluš Daniel
Publication year - 1977
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570140206
Subject(s) - chemistry , nitrile , ammonia , amide , derivative (finance) , catalysis , solvent , organic chemistry , medicinal chemistry , financial economics , economics
2‐Arnino‐3‐hydroxypyridine and its 6‐methyl derivative can be prepared in yields up to 55% by heating 2‐furoic acid derivatives at 200‐250° with ammonia in the presence of an acidic catalyst. The reaction is preferably conducted in an amide or a nitrile as solvent.