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Synthesis of fused ring 1,2,4‐triazoles by intramolecular cycloaddition of nitrile imines to the nitrile function
Author(s) -
Garanti Luisa,
Scandroglio Angelo,
Zecchi Gaetano
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130641
Subject(s) - nitrile , chemistry , cycloaddition , intramolecular force , ring (chemistry) , triethylamine , medicinal chemistry , stereochemistry , organic chemistry , catalysis
Treatment of 1‐chlorohydrazones (IIa‐c) with triethylamine gave fused ring 1,2,4‐triazoles arising from an intramolecular cycloaddition of the intermediate nitrile imines (IIIa‐c). This reaction was not observed in the case of one compound (IId) bearing an unactivated nitrile group.