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Transformations of some substituted methylene heterocycles with some nucleophiles
Author(s) -
DrobničKošorok M.,
JernejcPfundner K.,
Peternel J.,
Stanovnik B.,
Tišler M.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130626
Subject(s) - chemistry , isoquinoline , methylene , pyridazine , quinoline , hydrate , hydrazine (antidepressant) , pyridine , ring (chemistry) , nucleophile , organic chemistry , sodium hydroxide , medicinal chemistry , chromatography , catalysis
To the ring nitrogen substituted o ‐methylene derivatives of pyridine, pyridazine, quinoline and isoquinoline were transformed into the corresponding pyrazolyl derivatives when treated with hydrazine hydrate. On the other hand, the substituted methylene derivatives of quinoline or isoquinoline were transformed with aqueous sodium hydroxide or with sodium ethylate into 2‐methylquinoline or 1‐methylisoquinoline. This reaction represents a facile introduction of a methyl group in the above mentioned heterocycles.