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Reaction of hydrazidic halides with cyanoacetic acid derivatives
Author(s) -
Shawali Ahmad S.,
Hassaneen H. M.,
Sami M.,
Fahham H. M.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130547
Subject(s) - chemistry , cyanoacetic acid , sodium ethoxide , ethyl cyanoacetate , halide , ethanol , medicinal chemistry , elemental analysis , pyrazole , organic chemistry , malononitrile , polymer chemistry , catalysis
Ethyl cyanoacetate reacts with the hydrazidic halides IV‐VI in presence of sodium ethoxide in ethanol at room temperature to give the pyrazole derivatives VIII‐X respectively. Similar treatment of IV‐VIII with cyanoacetanilide gives the substituted pyrazoles XI‐XIV respectively. The results show that IV to VIII, unlike I, follow one and the same sequence in their reactions with cyanoacetic acid derivatives. The structure assignments of the products VIII‐XIV were based on elemental analysis and spectral evidence.