Premium
[1,3,5]Triazino[1,2‐ a ] azepines: A new ring system
Author(s) -
Bigg D. C. H.,
Purvis S. R.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130541
Subject(s) - azepine , chemistry , cycloheptene , ring (chemistry) , cycloaddition , aryl , computational chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , alkyl
The reaction of 2‐pyrrolidino‐1‐aza‐1‐cycloheptene with aryl isocyanates leads, via 1,4‐dipolar cycloaddition, to 1,3‐diaryl‐10a‐pyrrolidinoperhydro[1,3,5]triazino[1,2‐ a ]azepine‐2,4‐diones. The reaction provides a facile route to the novel [1,3,5]triazino[1,2‐ a ]azepine ring system.