Premium
Carbonation of 3‐pyridinols
Author(s) -
Mutterer F.,
Weis C. D.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130536
Subject(s) - chemistry , carbonation , phosgene , pyridine , ammonia , liquid ammonia , organic chemistry , medicinal chemistry
Procedures are described for the high pressure carbonation of substituted 3‐pyridinols, yielding the corresponding pyridine carboxylic acids. Treatment of o ‐aminohydroxypyridinecarboxylic acid with cyanogen and with phosgene, respectively, gave access to oxazolo[4,5‐ b ]pyridine derivatives. The synthesis of 3‐amino‐6‐methyl‐2‐pyridinecarboxylic acid was accomplished by heating 3‐hydroxy‐6‐methyl‐2‐pyridinecarboxylic acid in liquid ammonia.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom