Premium
Carbonation of 3‐pyridinols
Author(s) -
Mutterer F.,
Weis C. D.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130536
Subject(s) - chemistry , carbonation , phosgene , pyridine , ammonia , liquid ammonia , organic chemistry , medicinal chemistry
Abstract Procedures are described for the high pressure carbonation of substituted 3‐pyridinols, yielding the corresponding pyridine carboxylic acids. Treatment of o ‐aminohydroxypyridinecarboxylic acid with cyanogen and with phosgene, respectively, gave access to oxazolo[4,5‐ b ]pyridine derivatives. The synthesis of 3‐amino‐6‐methyl‐2‐pyridinecarboxylic acid was accomplished by heating 3‐hydroxy‐6‐methyl‐2‐pyridinecarboxylic acid in liquid ammonia.