Premium
Hashish (1): Ceric ammonium nitrate oxidation of Δ 6a, 1 0 a ‐tetrahydrocannabinols (THC's)
Author(s) -
Razdan Raj K.,
Dalzell Haldean C.,
Herlihy Patricia
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130535
Subject(s) - ceric ammonium nitrate , chemistry , ammonium nitrate , ammonium , nitrate , organic chemistry , nuclear chemistry , medicinal chemistry , grafting , polymer
A procedure is described for the conversion of acetates of Δ 6a, 1 0 a ‐THC's ( 2 and 4a ) to their corresponding 7‐oxo‐derivatives ( 3a , b , d and 4b ) by oxidation with ceric ammonium nitrate. The differences between the nmr spectra of these 7‐oxo‐derivatives and the 10‐oxo‐THC (1) are discussed. The 7‐oxo‐derivatives show THC‐like activity in mice albeit less than their corresponding THC's.