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On the grignard reaction of 2‐bromo‐3‐iodo‐ and 3‐bromo‐2‐chlorothiophene
Author(s) -
Gronowitz Salo,
Pettersson Kerstin
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130534
Subject(s) - chemistry , thiophene , halide , grignard reaction , magnesium , medicinal chemistry , halo , grignard reagent , organic chemistry , catalysis , reagent , physics , quantum mechanics , galaxy
2‐Bromo‐3‐iodo‐ and 3‐bromo‐2‐chlorothiophene react with magnesium in the presence of 1,2‐dibrornoethane to give 2‐halo‐3‐thiophene magnesium halide which opens a useful route to 2,3‐disubstituted thiophenes having an electron‐withdrawing group in the 3‐position.