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Improved syntheses of 5‐substituted‐4‐amino‐3‐mercapto‐(4 H )‐1,2,4‐triazoles
Author(s) -
Reid Jack R.,
Heindel Ned D.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130450
Subject(s) - chemistry , ring (chemistry) , potassium , combinatorial chemistry , stereochemistry , organic chemistry
Two improved methods have been developed for the synthesis of 5‐substiluted‐4‐amino‐3‐mercapto‐(4 H )‐1,2,4‐triazoles. One of these involves the direct hydrazinolysis of potassium 3‐aroyldithiocarbazates and the other involves ring‐opening and reclosure of 5‐substituted‐2‐mereapto‐1,3,4‐oxadiazoles to the aminomercaptotriazoles. Both of these methods offer advantages over the classic Hoggarth synthesis.