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Synthesis of hydroxy‐6 H ‐benzofuro[3,2‐ c ] [1]benzopyran‐6‐ones
Author(s) -
McPherson H. L.,
Ponder B. W.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130446
Subject(s) - chemistry , benzopyran , hydrochloride , anhydrous , pyridine , medicinal chemistry , stereochemistry , organic chemistry
The Micheal addition of ethyl 2‐methoxy‐, 2,4‐dimethoxy‐ and 2,5‐dimethoxybenzoylacetates with benzoquinone leads to ethyl 2‐(rnethoxy or dimethoxy phenyl)‐5‐hydroxybenzofuran 3‐carboxylates. Treatment of the henzofuran derivatives with anhydrous pyridine hydrochloride at 190–195° leads to hydroxy‐6 H ‐henzofuro[3,2‐c] [1]benzopyran‐6‐ones.