The reaction of 1‐azirines with 2‐pyridyl isothiocyanate: Possible approaches to benzodiazepine and benzodiazepine derivatives | Zendy

Nair V. | Zendy; Kim K. H. | Zendy

Premium

The reaction of 1‐azirines with 2‐pyridyl isothiocyanate: Possible approaches to benzodiazepine and benzodiazepine derivatives

Author(s) -

Nair V.,

Kim K. H.

Publication year - 1976

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570130434

Subject(s) - chemistry , isothiocyanate , pyridazine , azide , cycloaddition , azirine , pyrrole , thermal decomposition , pyrazine , dimer , phenyl isothiocyanate , medicinal chemistry , benzodiazepine , ring (chemistry) , stereochemistry , organic chemistry , catalysis , biochemistry , receptor

The structure of the dimer ( 5 ) from 2‐pyridyl isothiocyanate ( 1 ) has been confirmed by 13 C nmr spectral studies. The cycloaddition of 2‐pyridyl isothiocyanate with 1‐azirines results in the formation of thiazoles ( 10 ). Thermal decomposition of the vinyl azide ( 14 ) gives the pyrrole ( 15 ) and the pyridazine ( 16 ) instead of 2‐(2‐pyridyl)‐1‐azirine ( 12 ).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research