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Heterocyclic compounds. VII. Synthesis of thiadiazasteroid analogs
Author(s) -
Manhas M. S.,
Rao V. V.,
Amin S. G.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130425
Subject(s) - chemistry , chloride , steroid , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , hormone
The synthesis of a number of β‐northiadiaza steroid analogs has been described. Suitable o ‐aminonitriles were acylated with γ‐chlorobutyryl chloride. These amidonitriles were cyclized to substituted γ‐lactams and subsequently to the tetracyclic products. To functionalize the “17‐position” in these steroids, the intermediate γ‐lactams were converted to arylidene derivatives before cyclization to the tetracyclic derivatives.