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Some reactions of 1‐lithio‐2‐ n ‐butyl‐1,2‐dihydropyridine. VI. Synthesis of β‐substituted pyridines
Author(s) -
Knaus E. E.,
Ondrus T. A.,
Giam C. S.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130420
Subject(s) - chemistry , reagent , pyridine , electrophile , dihydropyridine , medicinal chemistry , ion , organic chemistry , catalysis , calcium
Reaction of the ambident anion 1‐lithio‐2‐ n ‐butyl‐1,2‐dihydropyridine ( 1 ) with several electrophilic reagents has been investigated. Direct methods for the introduction of amino, bromo, β‐pyridyl, arylselenyl, alkanesulfonyl and methyl substituents into the β‐position of pyridine are described.