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Synthesis of 1‐alkyl‐5‐phenyl‐4(1 H )pyrimidinones
Author(s) -
Beck James R.,
Gajewski Robert P.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130337
Subject(s) - chemistry , pyrimidinones , alkyl , methylene , acetal , amine gas treating , dimethylformamide , medicinal chemistry , organic chemistry , solvent
1‐Alkyl‐5‐phenyl‐4(1 H )pyrimidinones are readily synthesized by condensing β‐(dimethylamino)‐ N ‐[(dimethylamino)methylene] atropamides with methyl or ethyl amine. The latter compounds are prepared from phenylacetamides and dimethylformamide dimethyl acetal.
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