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An improved synthesis of norcocaine
Author(s) -
Stenberg V. I.,
Narain N. K.,
Singh S. P.,
Parmar S. S.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130231
Subject(s) - chemistry , benzoylecgonine , potassium permanganate , medicinal chemistry , organic chemistry , metabolite , biochemistry
An improved, high yielding procedure for the preparation of norcocaine from cocaine is described. The synthesis is accomplished by controlling the p H during the potassium permanganate oxidation. A quantitative conversion of N ‐benzoylecgonine methyl ester into norcocaine by dry, hydrogen chloride‐dioxane is also included.
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