Premium
Nuclear bishydroxylation with peroxydisulfate
Author(s) -
Rao Koppaka V.,
Owoyale Jacob A.
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130230
Subject(s) - peroxydisulfate , chemistry , yield (engineering) , derivative (finance) , methylation , medicinal chemistry , organic chemistry , catalysis , biochemistry , economics , financial economics , metallurgy , gene , materials science
Oxidation of 3,3′,4′,7‐tetra‐ O ‐methylquercelin by alkaline peroxydisulfate gave, in addition to the known 5,8‐dihydroxy derivative, a comparable yield of the 5,6,8‐trihydroxy compound. It was characterized by complete methylation and by conversion to the corresponding hydroxy and methoxy flavoquinones. Simultaneous introduction of two hydroxyls o ‐ and p ‐ to an existing hydroxyl function can be a potential step‐saver in the synthesis of polyphenolic substances.