Synthesis of 1,2,3‐thiadiazolo[4,5‐ d ] pyridazines, A new heterocyclic ring system | Zendy

Shafiee Abbas | Zendy

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Synthesis of 1,2,3‐thiadiazolo[4,5‐ d ] pyridazines, A new heterocyclic ring system

Author(s) -

Shafiee Abbas

Publication year - 1976

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570130220

Subject(s) - chemistry , pyridazine , ring (chemistry) , hydrazine (antidepressant) , hydrazone , medicinal chemistry , stereochemistry , organic chemistry , chromatography

A method was developed for the synthesis of 5‐carbethoxy‐4‐formyl‐1,2,3‐thiadiazole (I), its isomer (II); 5‐benzoyl‐4‐formyl‐1,2,3‐thiadiazole (III), and its isomer (IV). It was demonstrated that although compounds I, III and IV with hydrazine gave 7 H ‐1,2,3‐thiadiazolo[4,5‐ d ]‐pyridazin‐7‐one (XXII), 7‐phenyl‐1,2,3‐thiadiazolo[4,5‐ d ]pyridazine (XXIII) and 4‐phenyl‐1,2,3‐thiadiazolo[4,5‐ d ]pyridazine (XXV), respectively; however, compound I gave its corresponding hydrazone (XXIV).

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