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Synthesis of 1,2,3‐thiadiazolo[4,5‐ d ] pyridazines, A new heterocyclic ring system
Author(s) -
Shafiee Abbas
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130220
Subject(s) - chemistry , pyridazine , ring (chemistry) , hydrazine (antidepressant) , hydrazone , medicinal chemistry , stereochemistry , organic chemistry , chromatography
A method was developed for the synthesis of 5‐carbethoxy‐4‐formyl‐1,2,3‐thiadiazole (I), its isomer (II); 5‐benzoyl‐4‐formyl‐1,2,3‐thiadiazole (III), and its isomer (IV). It was demonstrated that although compounds I, III and IV with hydrazine gave 7 H ‐1,2,3‐thiadiazolo[4,5‐ d ]‐pyridazin‐7‐one (XXII), 7‐phenyl‐1,2,3‐thiadiazolo[4,5‐ d ]pyridazine (XXIII) and 4‐phenyl‐1,2,3‐thiadiazolo[4,5‐ d ]pyridazine (XXV), respectively; however, compound I gave its corresponding hydrazone (XXIV).