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1,8‐naphthyridines. Part II. Synthesis of some 3‐pyridyl‐5,7‐di(trifluoromethyl)‐1,8‐naphthyridin‐2(1 H )ones
Author(s) -
Eichler Eva,
Rooney Clarence Stanley,
Williams Haydn Windsor Richard
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130107
Subject(s) - chemistry , trifluoromethyl , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , alkyl
Ethyl 2‐amino‐4,6‐di(trifluoromethyl)nicotinate was prepared and its use as an intermediate in the synthesis of two 3‐pyridyl‐5,7‐di(trifluoromethyr)‐1,8‐naphthyridin‐2(1 H )ones is presented. A dimer of 2‐amino‐4,6‐di(trifluoromethyl)nieotinaldehyde is described.
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