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1,8‐Naphthyridines. Part I. Synthesis of some trifluoromethyl‐1,8‐naphthyridine derivatives
Author(s) -
Eichler Eva,
Rooney Clarence Stanley,
Williams Haydn Windsor Richard
Publication year - 1976
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570130106
Subject(s) - chemistry , trifluoromethyl , oxidizing agent , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , alkyl
The synthesis of some 2‐amino‐1,8‐naphthyridine derivatives substituted in the 5‐ and/or 7‐positions with trifluoromethyl is described along with their conversions to the corresponding 1,8‐naphthyridin‐2(1 H )ones. A modified procedure for oxidizing electron‐deficient heterocyclic compounds to their N ‐oxides is presented.
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