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Studies on the syntheses of heterocyclic compounds. Part DCXXXII . The formation of the benzimidazo[2,1‐ a ]isoquinoline by reaction of the 1,2,3,4‐tetrahydro‐1‐(2‐nitrophenethyl)isoquinoline with triethyl phosphite
Author(s) -
Kametani Tetsuji,
Fujimoto Yasuo,
Mizushima Masakatsu
Publication year - 1975
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570120632
Subject(s) - isoquinoline , chemistry , organic chemistry , medicinal chemistry
Abstract Reductive cyclization of 1,2,3,4‐tetrahydro‐6,7‐dimethoxy‐1‐(4,5‐dimethoxy‐2‐nitrophen‐ethyl)isoquinoline (V) with triethyl phosphite gave 5,6‐dihydro‐2,3,9,10‐tetramethoxybenzimidazo[2,1‐ a ]isoquinoline (IX), whose structure was identified by the spectroscopic analyses by an alternative synthesis.