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Studies on quinoline derivatives and related compounds. III. A novel pyridine synthesis to give substituted 1,4‐dihydro‐4‐oxonicotinic acids
Author(s) -
Agui Hideo,
Tobiki Hisao,
Nakagome Takenari
Publication year - 1975
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570120629
Subject(s) - chemistry , quinoline , pyridine , combinatorial chemistry , organic chemistry
A variety of 5‐mono‐ and 5,6‐disubstituted 1,4‐dihydro‐4‐oxonicotinates were prepared by a novel pyridine synthesis which involves thermal cyclisation of enaminomethylenemalonates 9. The intermediates 9 were readily prepared through a few steps from commercially available starting materials.