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The synthesis of pyrimido[4,5‐ c ] pyridazines and pyrido[2,3‐ d ]pyrimidines related to toxoflavin and fervenulin
Author(s) -
Billings Bernadette Kuo,
Wagner Judith A.,
Dan Cook Phillip,
Castle Raymond N.
Publication year - 1975
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570120625
Subject(s) - chemistry , stereochemistry , combinatorial chemistry , medicinal chemistry
4‐Deazatoxoflavin (1,6‐dimethyl‐1,5,6,7‐tetrahydropyrimido[4,5‐ c ]‐5,7‐pyridazinedione) ( 7 ) and several other 4‐deazatoxoflavin and 4‐deazafervenulin analogs have been prepared with the required intermediates. 3,5,7‐Trimethyl‐1,2,3,4‐tetrahydropyrido[2,3‐ d ]‐2,4‐pyrimidinedione ( 19 ) and 8‐phenyl‐3,5,7‐trimethyl‐2,3,4,8‐tetrahydropyrido[2,3‐ d ]‐2,4‐pyrimidinedione ( 20 ) were also prepared.