The synthesis of pyrimido[4,5‐ c ] pyridazines and pyrido[2,3‐ d ]pyrimidines related to toxoflavin and fervenulin | Zendy

Billings Bernadette Kuo | Zendy; Wagner Judith A. | Zendy; Dan Cook Phillip | Zendy; Castle Raymond N. | Zendy

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The synthesis of pyrimido[4,5‐ c ] pyridazines and pyrido[2,3‐ d ]pyrimidines related to toxoflavin and fervenulin

Author(s) -

Billings Bernadette Kuo,

Wagner Judith A.,

Dan Cook Phillip,

Castle Raymond N.

Publication year - 1975

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570120625

Subject(s) - chemistry , stereochemistry , combinatorial chemistry , medicinal chemistry

4‐Deazatoxoflavin (1,6‐dimethyl‐1,5,6,7‐tetrahydropyrimido[4,5‐ c ]‐5,7‐pyridazinedione) ( 7 ) and several other 4‐deazatoxoflavin and 4‐deazafervenulin analogs have been prepared with the required intermediates. 3,5,7‐Trimethyl‐1,2,3,4‐tetrahydropyrido[2,3‐ d ]‐2,4‐pyrimidinedione ( 19 ) and 8‐phenyl‐3,5,7‐trimethyl‐2,3,4,8‐tetrahydropyrido[2,3‐ d ]‐2,4‐pyrimidinedione ( 20 ) were also prepared.

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