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Preparation of 4,6‐diaminopyrazolo[3,4‐ d ] pyrimidines with variations in substitution at the 1‐ and 3‐positions
Author(s) -
Southwick Philip L.,
Dhawan Balram
Publication year - 1975
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570120621
Subject(s) - chemistry , formamide , substitution (logic) , pyrimidine , triethanolamine , substitution reaction , stereochemistry , medicinal chemistry , organic chemistry , analytical chemistry (journal) , computer science , programming language
A number of new derivatives of 4,6‐diaminopyrazolo[3,4‐ d ]pyrimidines substituted in the 1‐ and/or 3‐positions have been obtained from reactions of guanidine carbonate with 1‐ and/or 3‐substituted‐5‐amino‐4‐cyanopyrazoles. Use of triethanolamine as a reaction medium permitted preparation of certain derivatives which could not be obtained from the previously described fusion procedure. Some derivatives of 4‐aminopyrazolo[3,4‐ d ]pyrimidine with substitution at the 1 ‐ and/or 3‐positions were also obtained from reactions of formamide with the same 5‐amino‐4‐cyanopyrazoles. The new compounds were screened for in vivo antimalarial activity, but were found inactive.