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Reductive acetylation of nitro compounds. III. Chemical transformations in three thiophene systems
Author(s) -
Klemm L. H.,
Hsin Wilson
Publication year - 1975
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570120618
Subject(s) - chemistry , thiophene , acetic anhydride , nitro , acetic acid , acetylation , ring (chemistry) , medicinal chemistry , organic chemistry , catalysis , biochemistry , alkyl , gene
Nitro groups on thiophene ring systems are transformed directly into acetylamino functions in yields of 61–82% by means of a mixture of iron, acetic acid, and acetic anhydride at 50–105°. When a bromo suhstituent is also present on the ring partial hydrodebromination occurs during the reaction.