The direct thionation and aminoalkylation of pyridine 1‐oxides and related reactions | Zendy

Abramovitch Rudolph A. | Zendy; Knaus Edward E. | Zendy

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The direct thionation and aminoalkylation of pyridine 1‐oxides and related reactions

Author(s) -

Abramovitch Rudolph A.,

Knaus Edward E.

Publication year - 1975

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570120414

Subject(s) - chemistry , pyridine , sulfur , oxide , ethylene , ethylene oxide , antifungal , organic chemistry , oxygen , catalysis , medicine , dermatology , copolymer , polymer

The reaction of lithiopyridine 1‐oxides with oxygen gives poor yields of 1‐hydroxy‐2‐pyridones. The reaction with sulfur, however, is a convenient route to the 1‐hydroxy‐2‐pyridinethiones which have useful antibacterial and antifungal activity. Reaction with ethylene oxide gives mainly polymeric products, but addition to Shiff's bases promises to be a convenient mode of mono‐, and particularly di‐α‐aminoalkylation of pyridine 1‐oxides.

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