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The cyclocondensation of 5‐amino‐1,3‐dimethylpyrazole with ethyl acetoacetate. Synthesis of isomeric pyrazolopyridones
Author(s) -
Ratajczyk James D.,
Swett Leo R.
Publication year - 1975
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570120315
Subject(s) - chemistry , ethyl acetoacetate , stereochemistry , organic chemistry , medicinal chemistry , catalysis
The reaction of 5‐amino‐1,3‐dimethylpyrazole with ethyl acetoacetate yielded two isomeric pyrazolopyridones which were identified as their corresponding tetrahydropyrazolopyridine derivatives and by their ir, pmr and 13 C‐nmr spectral data. Additional proof was provided by a separate synthetic route involving the Friedländer reaction.