Premium
Novel polycyclic heterocycles. XIV. 1,2‐Dihydro‐4‐(trifluoromethyl)‐3 H ‐8 H ‐quino[1,8‐ ab ][4,1]benzoxazepin‐3‐one and its derivatives
Author(s) -
Yale Harry L.,
Bristol James A.,
Petigara Ramesh B.
Publication year - 1975
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570120309
Subject(s) - chemistry , trifluoromethyl , hydroxylamine , reactivity (psychology) , component (thermodynamics) , medicinal chemistry , organic chemistry , stereochemistry , medicine , alkyl , alternative medicine , physics , pathology , thermodynamics
Procedures for the isolation of 1,2‐dihydro‐4‐(trifluoromethyl)‐3 H ,8 H ‐quino[1,8‐ ab ][4,1]‐benzoxazepine, 3 , from reaction mixtures containing 3 as the minor component, and the isomer, 1,2‐dihydro‐11‐(trifluoromethyl)‐3 H ,7 H ‐quino[8,1‐ cd ][1,5]benzoxazepin‐3‐one, 2 , as the major component, are described. The reactivity of 3 toward hydroxylamine and aromatic aldehydes has been investigated and the preparation of derivatives with those reactants is described.