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N 1 ‐Substitution in 2‐methyl‐4(5)nitroimidazole. III. New syntheses of 1‐(2′‐(ethylsulfonyl)ethyl)‐2‐methyl‐5‐nitroimidazole
Author(s) -
Čaplar V.,
Šunjić V.,
Kafjež F.
Publication year - 1974
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570110636
Subject(s) - nitroimidazole , chemistry , substitution (logic) , medicinal chemistry , organic chemistry , stereochemistry , combinatorial chemistry , programming language , computer science
Some new syntheses of 1‐[2′‐(ethylsulfonyl)ethyl]‐2‐methyl‐5‐nitroimidazole (IV), a new antitrichomonal agent are described. The most successful method proved to be alkylation of sodium ethanesulfinate (XXI) with 1‐(2′‐haloethyl)‐2‐methyl‐5‐nitroimidazoles (1a,b) in dimethylformamide.