Bridged 1,4‐benzoxazocines from 5‐hydroxy‐3‐phenyl‐2‐benzofuranone | Zendy

Zaugg H. E. | Zendy; Holland J. B. | Zendy; Dunnigan D. A. | Zendy; Denet R. W. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Bridged 1,4‐benzoxazocines from 5‐hydroxy‐3‐phenyl‐2‐benzofuranone

Author(s) -

Zaugg H. E.,

Holland J. B.,

Dunnigan D. A.,

Denet R. W.

Publication year - 1974

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570110619

Subject(s) - chemistry , ring (chemistry) , stereochemistry , series (stratigraphy) , group (periodic table) , analogy , medicinal chemistry , organic chemistry , paleontology , linguistics , philosophy , biology

A previously described neighboring group reaction has been extended to the synthesis of hydroxy‐substituted bridged 1,4‐benzoxazocines ( i.e. , 7, 8 ) bearing a structural analogy to potent analgetics of the hydroxy‐6,7‐benzomorphan series. In contrast to the latter, the presence of a hydroxyl group in the aromatic ring of the present series destroys all analgesic activity possessed by the unsubstituted system.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research