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Ring closure, of 2‐benzylamino‐1‐phenylethanols to 4‐phenyltetrahydroisoquinolines
Author(s) -
Schwan Thomas J.,
Lougheed Guy S.,
Burrous Stanley E.
Publication year - 1974
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570110527
Subject(s) - chemistry , scope (computer science) , closure (psychology) , ring (chemistry) , mechanism (biology) , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , programming language , economics , market economy , philosophy , epistemology , computer science
The, facile preparation of 4‐pbenyltetrabydroisoquinolines by the acid‐catalyzed cyclization of 2‐benzylamino‐1‐pbenyletbanols and related compounds is described along with a discussion of the scope, limitations, and possible mechanism of the reaction.