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Novel polycyclic heterocyeles. XIII. Derivatives of the oxime and carbinol derived from 1,2‐dihydro‐11‐(trifluoromethyl)‐3 H ,7 H ‐quino[8,1‐ cd ] [1,5]benzoxazepin‐3‐one
Author(s) -
Yale Harry L.,
Petigara Ramesh B.
Publication year - 1974
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570110524
Subject(s) - chemistry , phenylisocyanate , oxime , yield (engineering) , sodium hydride , trifluoromethyl , medicinal chemistry , chloride , hydride , organic chemistry , alkyl , sodium , metal , materials science , metallurgy
The anions derived from the oxime, 2 , and the carbinol, 3 , generated by reaction with sodium hydride, were reacted with aminoalkyl chlorides and an aroyl chloride to give a number of amino‐alkyl ethers and an aroyl ester. In addition, 2 and 3 were reacted with phenylisocyanate to yield O ‐phenylcarbamoyl derivatives. The pmr spectra of several of these compounds are discussed.